{"id":7836,"date":"2025-07-02T03:28:51","date_gmt":"2025-07-01T19:28:51","guid":{"rendered":"https:\/\/allcancer.com\/cancer\/polycythemia-vera-pv-2\/"},"modified":"2025-07-02T11:22:11","modified_gmt":"2025-07-02T03:22:11","slug":"%e7%9c%9f%e6%80%a7%e5%a4%9a%e8%a1%80%e7%97%87-pv-%e7%99%8c%e7%97%87%e9%a1%9e%e5%9e%8b","status":"publish","type":"cancer_type","link":"https:\/\/allcancer.com\/hk\/%e7%99%8c%e7%97%87\/%e7%9c%9f%e6%80%a7%e5%a4%9a%e8%a1%80%e7%97%87-pv-%e7%99%8c%e7%97%87%e9%a1%9e%e5%9e%8b\/","title":{"rendered":"\u591a\u8840\u7403\u53e2\u751f\u75c7 (PV)"},"content":{"rendered":"<h2 class=\"h2-cancertype\">\u4ec0\u9ebc\u662f <strong>\u591a\u8840\u7403\u53e2\u751f\u75c7 (PV)<\/strong>?<\/h2>\n<p class=\"p-cancertype\">\u591a\u8840\u7403\u7624 (PV) \u662f\u4e00\u7a2e\u7f55\u898b\u7684\u6162\u6027\u8840\u764c\uff0c\u7279\u5fb5\u662f\u9aa8\u9ad3\u4e2d\u7d05\u8840\u7403\u7570\u5e38\u3001\u7121\u6cd5\u63a7\u5236\u7684\u589e\u751f\u3002\u9019\u7a2e\u589e\u751f\u6703\u5c0e\u81f4\u8840\u6db2\u8b8a\u7a20\uff08\u9ecf\u7a20\u5ea6\u904e\u9ad8\uff09\uff0c\u986f\u8457\u589e\u52a0\u8840\u6813\uff08\u8840\u584a\uff09\u3001\u4e2d\u98a8\u548c\u5fc3\u81df\u75c5\u767c\u4f5c\u7684\u98a8\u96aa\u3002<\/p>\n<p class=\"p-cancertype\">\u7684\u751f\u7269\u57fa\u790e <strong>\u591a\u8840\u7403\u53e2\u751f\u75c7 (PV)<\/strong> \u4e3b\u8981\u570d\u7e5e\u4e00\u7a2e\u7a31\u70ba JAK2 V617F \u7684\u7a81\u8b8a\u3002\u9019\u7a2e\u907a\u50b3\u7570\u5e38\u6703\u7834\u58de\u6b63\u5e38\u7684\u7d30\u80de\u8a0a\u865f\u901a\u8def\uff0c\u523a\u6fc0\u9aa8\u9ad3\u904e\u5ea6\u88fd\u9020\u7d05\u8840\u7403\u3002\u7814\u7a76\u4eba\u54e1\u5f37\u8abf\u764c\u75c7\u751f\u7269\u5b78\u4e2d\u7684\u4e00\u500b\u91cd\u8981\u7279\u5fb5\uff1a\u300c\u6c83\u4f2f\u683c\u6548\u61c9\u300d\uff0c\u764c\u7d30\u80de (\u5305\u62ec\u8207 PV \u6709\u95dc\u7684\u764c\u7d30\u80de) \u7531\u65bc\u65b0\u9673\u4ee3\u8b1d\u72c0\u614b\u6539\u8b8a\uff0c\u6d88\u8017\u8461\u8404\u7cd6\u7684\u901f\u5ea6\u662f\u6b63\u5e38\u7d30\u80de\u7684 200 \u500d\u3002<\/p>\n<h3 class=\"h3-cancertype\">\u6d41\u884c\u75c5\u5b78\uff1a\u9999\u6e2f\u548c\u4e9e\u6d32\u7279\u6709\u7684\u8003\u616e\u56e0\u7d20<\/h3>\n<p class=\"p-cancertype\">\u591a\u8840\u7d30\u80de\u53e2\u751f\u75c7\uff08Polycythemia Vera\uff0c\u7c21\u7a31 PV\uff09\u7684\u5168\u7403\u767c\u75c5\u7387\u7d04\u70ba\u6bcf\u5e74\u6bcf 10 \u842c\u4eba\u4e2d 2 \u81f3 3 \u4f8b\uff0c50 \u81f3 70 \u6b72\u7537\u6027\u7684\u8ca0\u64d4\u5c24\u5176\u6c89\u91cd\u3002\u5728\u9999\u6e2f\u53ca\u4e9e\u6d32\u5404\u5730\uff0c\u78ba\u5207\u7684\u767c\u75c5\u7387\u4ecd\u672a\u5f97\u5230\u5145\u5206\u7814\u7a76\u3002\u5118\u7ba1\u5982\u6b64\uff0c\u65b0\u8208\u8cc7\u6599\u986f\u793a\u9019\u4e9b\u65cf\u7fa4\u5c0d\u6b64\u75c5\u7684\u8a8d\u77e5\u8207\u8a3a\u65b7\u983b\u7387\u6b63\u5728\u589e\u52a0\u3002<\/p>\n<ul class=\"p-cancertype\">\n<li>\u5168\u7403\u767c\u75c5\u7387\uff1a\u6bcf\u5e74\u6bcf 100,000 \u4eba\u4e2d\u7d04\u6709 2.8 \u4eba\u3002<\/li>\n<li>\u4ee5\u4e2d\u8001\u5e74\u4eba\u5c45\u591a\uff1a\u9ad8\u5cf0\u767c\u75c5\u5e74\u9f61\u70ba 50 \u81f3 70 \u6b72\u3002<\/li>\n<li>\u7537\u6027\u53d7\u5f71\u97ff\u7684\u7a0b\u5ea6\u6bd4\u5973\u6027\u7565\u9ad8\u3002<\/li>\n<li>\u4e9e\u6d32\u5730\u5340\u7f3a\u4e4f\u5168\u9762\u7684\u8a3b\u518a\u8cc7\u6599\uff0c\u7a81\u986f\u51fa\u5728\u9999\u6e2f\u52a0\u5f37\u8a8d\u77e5\u548c\u7be9\u6aa2\u7684\u8feb\u5207\u6027\u3002<\/li>\n<\/ul>\n<p class=\"p-cancertype\">\u591a\u8840\u75c7\u97cb\u62c9\u6703\u5e36\u4f86\u8eab\u9ad4\u548c\u60c5\u7dd2\u4e0a\u7684\u5f71\u97ff\uff0c\u5f9e\u75b2\u52de\u3001\u982d\u75db\u3001\u6688\u7729\u5230\u7126\u616e\u548c\u751f\u6d3b\u54c1\u8cea\u4e0b\u964d\u7b49\u986f\u8457\u7684\u793e\u6703\u5fc3\u7406\u5f71\u97ff\u3002\u60a3\u8005\u7d93\u5e38\u6703\u6709\u96b1\u85cf\u7684\u75c7\u72c0\uff0c\u9664\u975e\u7d93\u904e\u7279\u5225\u7684\u6aa2\u6e2c\uff0c\u5426\u5247\u5e38\u6703\u88ab\u4f8b\u884c\u6027\u7684\u91ab\u7642\u7167\u8b77\u6240\u5ffd\u7565\uff0c\u56e0\u6b64\u75be\u75c5\u7684\u8a8d\u77e5\u8207\u65e9\u671f\u6aa2\u6e2c\u662f\u975e\u5e38\u91cd\u8981\u7684\u3002<\/p>\n<p class=\"p-cancertype\"><em>\u9032\u4e00\u6b65\u4e86\u89e3\u8840\u6db2\u764c\u75c7\u548c\u4ee3\u8b1d\u816b\u7624\u5b78\u7684\u76f8\u95dc\u8cc7\u8a0a\uff0c\u8acb\u53c3\u95b1\u6211\u5011\u7684 <a href=\"\/hk\/cancer-biology\/\">\u764c\u75c7\u751f\u7269\u5b78<\/a> \u90e8\u5206\u6216\u6211\u5011\u7684\u52d5\u614b <a href=\"\/hk\/advanced-diagnostics\/\">\u9032\u968e\u8a3a\u65b7\u670d\u52d9<\/a> \u5728 AllCancer\u3002<\/em><\/p>\n<h2 class=\"h2-cancertype\">\u591a\u8840\u75c7\u97cb\u62c9 (PV) \u7684\u6210\u56e0\u8207\u98a8\u96aa\u56e0\u7d20<\/h2>\n<p class=\"p-cancertype\">\u77ad\u89e3 <strong>\u591a\u8840\u75c7\u97cb\u62c9 (PV) \u7684\u6210\u56e0<\/strong> \u5c0d\u65bc\u7cbe\u78ba\u8a3a\u65b7\u3001\u65e9\u671f\u6aa2\u6e2c\u53ca\u6709\u6548\u7ba1\u7406\u81f3\u95dc\u91cd\u8981\u3002PV \u4e3b\u8981\u4f86\u81ea\u65bc\u907a\u50b3\u548c\u65b0\u9673\u4ee3\u8b1d\u7684\u6539\u8b8a\uff0c\u901a\u5e38\u6703\u56e0\u70ba\u5916\u5728\u74b0\u5883\u548c\u751f\u6d3b\u65b9\u5f0f\u7684\u5f71\u97ff\u800c\u60e1\u5316\u3002<\/p>\n<h3 class=\"h3-cancertype\">PV \u7684\u907a\u50b3\u548c\u751f\u7269\u56e0\u7d20<\/h3>\n<p class=\"p-cancertype\">\u591a\u8840\u75c7\u97cb\u62c9 (PV) \u7684\u4e3b\u8981\u907a\u50b3\u56e0\u5b50\u662f JAK2 V617F \u8b8a\u7570\uff0c\u5728\u7d04 95% \u7684 PV \u75c5\u60a3\u4e2d\u767c\u73fe\u3002\u6b64\u7a81\u8b8a\u6703\u76f4\u63a5\u555f\u52d5\u8207\u7d05\u7d30\u80de\u904e\u5ea6\u88fd\u9020\u6709\u95dc\u7684\u8a0a\u865f\u901a\u8def\u3002\u5176\u4ed6\u8f03\u4e0d\u5e38\u898b\u7684\u7a81\u8b8a (\u4f8b\u5982 JAK2 \u57fa\u56e0\u7b2c 12 \u500b\u5916\u986f\u5b50\u7684\u7a81\u8b8a) \u4e5f\u53ef\u80fd\u767c\u751f\u5728\u67d0\u4e9b PV \u75c5\u60a3\u8eab\u4e0a\u3002<\/p>\n<ul class=\"p-cancertype\">\n<li>JAK2 V617F \u57fa\u56e0\u7a81\u8b8a\uff1a\u5728\u7d04 95% \u7684 PV \u75c5\u4f8b\u4e2d\u6aa2\u6e2c\u5230\u3002<\/li>\n<li>\u5916\u663e\u5b50 12 \u7a81\u53d8\uff1a\u5728\u8f83\u5c0f\u7684 PV \u5b50\u96c6\u4e2d\u53d1\u73b0\uff0c\u4f46\u5177\u6709\u4e34\u5e8a\u610f\u4e49\u3002<\/li>\n<\/ul>\n<p class=\"p-cancertype\">PV \u764c\u7d30\u80de\u548c\u5176\u4ed6\u60e1\u6027\u816b\u7624\u4e00\u6a23\uff0c\u90fd\u6709\u7368\u7279\u7684\u65b0\u9673\u4ee3\u8b1d\u5f31\u9ede\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u5b83\u5011\u8868\u73fe\u51fa\u904e\u591a\u7684\u8461\u8404\u7cd6\u6d88\u8017\u548c\u8c37\u6c28\u9170\u80fa\u4f9d\u8cf4\u6027\u3002\u9019\u7a2e\u65b0\u9673\u4ee3\u8b1d\u7684\u4f9d\u8cf4\u6027\u63d0\u4f9b\u4e86\u5275\u65b0\u7684\u6cbb\u7642\u6a5f\u6703\uff0cAllCancer \u900f\u904e\u7a81\u7834\u6027\u7684\u65b0\u9673\u4ee3\u8b1d\u6cbb\u7642\u65b9\u6cd5\u4f86\u63a2\u7d22\u9019\u7a2e\u65b0\u9673\u4ee3\u8b1d\u7684\u4f9d\u8cf4\u6027\u3002<\/p>\n<h3 class=\"h3-cancertype\">PV \u7684\u74b0\u5883\u548c\u751f\u6d3b\u65b9\u5f0f\u56e0\u7d20<\/h3>\n<p class=\"p-cancertype\">\u96d6\u7136\u591a\u767c\u6027\u8840\u75c7(PV) \u4e3b\u8981\u4f86\u81ea\u57fa\u56e0\u7a81\u8b8a\uff0c\u4f46\u67d0\u4e9b\u74b0\u5883\u548c\u751f\u6d3b\u65b9\u5f0f\u56e0\u7d20\u53ef\u80fd\u6703\u4f7f\u500b\u4eba\u7684\u75c7\u72c0\u60e1\u5316\u6216\u51fa\u73fe\u4f75\u767c\u75c7\u3002\u751f\u6d3b\u578b\u614b\u7684\u56e0\u7d20\uff0c\u5305\u62ec\u5438\u7159\u3001\u8840\u6db2\u9ecf\u7a20\u5ea6\u5347\u9ad8\u53ca\u9ad8\u6d77\u62d4\u5c45\u4f4f\u74b0\u5883\uff0c\u90fd\u53ef\u80fd\u6703\u52a0\u91cd PV \u7684\u75c7\u72c0\u53ca\u6813\u585e\u98a8\u96aa\u3002<\/p>\n<ul class=\"p-cancertype\">\n<li>\u5438\u7159\uff1a\u6703\u986f\u8457\u63d0\u9ad8\u8840\u8272\u7d20\u548c\u8840\u6813\u98a8\u96aa\u3002<\/li>\n<li>\u9ad8\u6d77\u62d4\u66b4\u9732\uff1a\u4fc3\u7d05\u8840\u7d20\u7522\u751f\u589e\u52a0\u6703\u4f7f PV \u75c7\u72c0\u60e1\u5316\u3002<\/li>\n<li>\u7dca\u5f35\u7684\u751f\u6d3b\u65b9\u5f0f\uff1a\u53ef\u80fd\u6703\u52a0\u91cd\u75c5\u7a0b\u548c\u4f75\u767c\u75c7\u3002<\/li>\n<\/ul>\n<h3 class=\"h3-cancertype\">\u4e9e\u6d32\u7279\u6709\u7684\u98a8\u96aa\u56e0\u7d20\u548c\u5f71\u97ff<\/h3>\n<p class=\"p-cancertype\">\u96d6\u7136\u591a\u767c\u6027\u8840\u75c7(Polycythemia Vera, PV)\u7684\u98a8\u96aa\u56e0\u7d20\u662f\u666e\u904d\u5b58\u5728\u7684\uff0c\u4f46\u4e9e\u6d32\u5730\u5340\uff08\u5305\u62ec\u9999\u6e2f\uff09\u7684\u7279\u6b8a\u751f\u6d3b\u65b9\u5f0f\u548c\u74b0\u5883\u80cc\u666f\u53ef\u80fd\u6703\u6539\u8b8a\u75be\u75c5\u7684\u75c5\u7406\u5b78\u6216\u56b4\u91cd\u7a0b\u5ea6\u3002<\/p>\n<ul class=\"p-cancertype\">\n<li>\u4e9e\u88d4\u7537\u6027\u4f7f\u7528\u7159\u8349\u7684\u6bd4\u4f8b\u8f03\u9ad8\uff0c\u53ef\u80fd\u6703\u589e\u52a0 PV \u4f75\u767c\u75c7\u7684\u98a8\u96aa\u3002<\/li>\n<li>\u50cf\u9999\u6e2f\u9019\u6a23\u4eba\u53e3\u7a20\u5bc6\u7684\u5730\u5340\u5e38\u898b\u7684\u57ce\u5e02\u6c61\u67d3\u548c\u6162\u6027\u708e\u75c7\u74b0\u5883\u53ef\u80fd\u6703\u5f71\u97ff\u75be\u75c5\u7684\u767c\u5c55\u6216\u51dd\u8840\u529f\u80fd\u3002<\/li>\n<\/ul>\n<h3 class=\"h3-cancertype\">\u9810\u9632\u548c\u65e9\u671f\u6aa2\u6e2c\u7684\u91cd\u8981\u6027<\/h3>\n<p class=\"p-cancertype\">\u4f8b\u884c\u7be9\u6aa2\u53ca\u65e9\u671f\u767c\u73fe\u53ef\u5927\u5e45\u964d\u4f4e\u8207\u591a\u767c\u6027\u8840\u7403\u7624\u76f8\u95dc\u7684\u56b4\u91cd\u4f75\u767c\u75c7\u3002\u5b9a\u671f\u9032\u884c\u8840\u6db2\u5b78\u76e3\u6e2c\u3001\u53ca\u6642\u8fa8\u8b58\u907a\u50b3\u8b8a\u7570\uff0c\u4ee5\u53ca\u63d0\u4f9b\u751f\u6d3b\u65b9\u5f0f\u8f14\u5c0e\uff0c\u53ef\u6709\u6548\u8655\u7406\u591a\u767c\u6027\u8840\u75c7\u53e2\u751f\u7684\u8907\u96dc\u75c5\u7406\u3002<\/p>\n<ul class=\"p-cancertype\">\n<li>\u5efa\u8b70\u9ad8\u98a8\u96aa\u4eba\u58eb\u5b9a\u671f\u9032\u884c\u5168\u8840\u7d30\u80de\u8a08\u6578 (CBC)\u3002<\/li>\n<li>JAK2 \u57fa\u56e0\u7a81\u8b8a\u57fa\u56e0\u6e2c\u8a66\u5c0d\u8a3a\u65b7\u6e96\u78ba\u6027\u81f3\u95dc\u91cd\u8981\u3002<\/li>\n<li>\u65e9\u671f\u8840\u6db2\u5b78\u8aee\u8a62\u53ef\u6539\u5584\u9810\u5f8c\u4e26\u964d\u4f4e\u4f75\u767c\u75c7\u7684\u56b4\u91cd\u6027\u3002<\/li>\n<\/ul>\n<p class=\"p-cancertype\"><em>\u8acb\u9020\u8a2a\u6b0a\u5a01\u6a5f\u69cb\u9032\u884c\u9032\u4e00\u6b65\u95b1\u8b80\uff0c\u5305\u62ec <a href=\"https:\/\/www.cancer.gov\/\" target=\"_blank\" rel=\"noopener\">\u570b\u5bb6\u764c\u75c7\u7814\u7a76\u6240<\/a> \u548c <a href=\"https:\/\/www.who.int\/\" target=\"_blank\" rel=\"noopener\">\u4e16\u754c\u885b\u751f\u7d44\u7e54 (WHO)<\/a> \u4ee5\u7372\u5f97\u66f4\u591a\u6709\u95dc PV \u7684\u53ef\u4fe1\u6578\u64da\u3002<\/em><\/p>\n<p class=\"p-cancertype\">\u5728 AllCancer \u9ad4\u9a57\u8f49\u5316\u6027\u7684\u4ee3\u8b1d\u7642\u6cd5\uff0c\u958b\u5275\u764c\u75c7\u6162\u6027\u5316\u7642\u6cd5\u4f86\u7ba1\u7406\u591a\u8840\u7d30\u80de\u7624 (PV)\u3002\u63a2\u7d22\u6211\u5011\u7372\u5f97\u8afe\u8c9d\u723e\u734e\u652f\u6301\u7684\u7814\u7a76\u8207\u5148\u9032\u7684\u8a3a\u65b7\u6280\u8853\u5982\u4f55\u6709\u7cfb\u7d71\u5730\u6539\u5584\u75c5\u60a3\u7684\u7642\u6548\u8207\u751f\u6d3b\u54c1\u8cea\u3002<\/p>\n<p class=\"p-cancertype\"><em>\u77ad\u89e3\u66f4\u591a\u8cc7\u8a0a\u6216\u7acb\u5373\u9810\u7d04\u500b\u4eba\u5316\u8aee\u8a62\uff0c\u8acb\u9020\u8a2a\u6211\u5011\u7684 <a href=\"\/hk\/core-therapies\/\">\u6838\u5fc3\u6cbb\u7642<\/a> \u7bc0\u3002<\/em><\/p>\n<h2 class=\"h2-cancertype\">\u591a\u8840\u75c7\u97cb\u62c9 (PV) \u7684\u75c7\u72c0<\/h2>\n<p class=\"p-cancertype\">\u65e9\u671f\u767c\u73fe\u591a\u8840\u8272\u8108\u7624 (PV) \u53ef\u986f\u8457\u63d0\u9ad8\u6cbb\u7642\u6548\u679c\u548c\u75c5\u60a3\u7684\u751f\u6d3b\u54c1\u8cea\u3002\u8fa8\u8b58\u65e9\u671f\u75c7\u72c0\u4e26\u53ca\u6642\u5c31\u91ab\uff0c\u624d\u80fd\u6709\u6548\u63a7\u5236\u75c5\u60c5\u3002\u591a\u8840\u7d30\u80de\u53e2\u751f\u75c7 (PV) \u5e38\u898b\u7684\u7279\u5b9a\u75c7\u72c0\u5305\u62ec<\/p>\n<ul class=\"p-cancertype\">\n<li><strong>\u982d\u75db\uff1a<\/strong> \u5e38\u6301\u7e8c\u6216\u53cd\u8986\u767c\u751f\uff1b\u8207\u8840\u6db2\u9ecf\u7a20\u5ea6\u589e\u52a0\u548c\u5faa\u74b0\u53d7\u640d\u6709\u95dc\u3002<\/li>\n<li><strong>\u982d\u6688\u548c\u7729\u6688\uff1a<\/strong> \u7531\u65bc\u7d05\u8840\u7403\u542b\u91cf\u589e\u52a0\u5c0e\u81f4\u8166\u90e8\u704c\u6ce8\u53d7\u640d\u3002<\/li>\n<li><strong>\u7619\u7662\uff08\u7619\u7662\u75c7\uff09\uff1a<\/strong> \u5c24\u5176\u662f\u5728\u6eab\u6c34\u6c90\u6d74\u6216\u6dcb\u6d74\u4e4b\u5f8c\uff1b\u9019\u662f\u4e00\u7a2e\u514d\u75ab\u9a45\u52d5\u7684\u53cd\u61c9\uff0c\u8207\u8840\u6db2\u4e2d\u7d44\u80fa\u6fc3\u5ea6\u5347\u9ad8\u6709\u95dc\u3002<\/li>\n<li><strong>Reddened Complexion (Plethora)\uff1a<\/strong> \u7531\u65bc\u7d05\u7d30\u80de\u6578\u91cf\u589e\u52a0\uff0c\u901a\u5e38\u53ef\u898b\u65bc\u81c9\u9830\u3001\u9f3b\u5b50\u548c\u8033\u6735\u3002<\/li>\n<li><strong>\u75b2\u52de\uff1a<\/strong> \u5118\u7ba1\u7d05\u7d30\u80de\u589e\u52a0\uff0c\u4f46\u7531\u65bc\u6c27\u6c23\u8f38\u9001\u6548\u7387\u53d7\u640d\uff0c\u5c0e\u81f4\u6301\u7e8c\u75b2\u5026\u3002<\/li>\n<li><strong>\u547c\u5438\u6025\u4fc3\uff1a<\/strong> \u589e\u52a0\u5fc3\u8840\u7ba1\u7cfb\u7d71\u7684\u8ca0\u64d4\u3002<\/li>\n<li><strong>\u76dc\u6c57\uff1a<\/strong> \u555f\u52d5\u4ea4\u611f\u795e\u7d93\u7cfb\u7d71\u7684\u514d\u75ab\u548c\u767c\u708e\u53cd\u61c9\u3002<\/li>\n<li><strong>\u71d2\u707c\u75db\uff08Erythromelalgia\uff09\uff1a<\/strong> \u7531\u65bc\u5fae\u8840\u7ba1\u9589\u585e\u548c\u7f3a\u6c27\uff0c\u901a\u5e38\u6703\u9020\u6210\u624b\u90e8\u548c\u8173\u90e8\u7684\u5287\u70c8\u4e0d\u9069\u3002<\/li>\n<li><strong>\u8996\u529b\u554f\u984c\uff1a<\/strong> \u7531\u65bc\u9ad8\u7c98\u5ea6\u8a98\u767c\u8996\u7db2\u819c\u8840\u7ba1\u7d0a\u4e82\uff0c\u5c0e\u81f4\u8996\u529b\u6a21\u7cca\u6216\u91cd\u5f71\u3002<\/li>\n<li><strong>\u4e0d\u8cbb\u5439\u7070\u4e4b\u529b\u5c31\u80fd\u6e1b\u80a5\uff1a<\/strong> \u8207\u7570\u5e38\u7d30\u80de\u589e\u6b96\u7684\u9ad8\u4ee3\u8b1d\u6d3b\u52d5\u6709\u95dc\u3002<\/li>\n<li><strong>\u9ebb\u6728\u6216\u523a\u75db\uff08\u795e\u7d93\u75c5\u8b8a\uff09\uff1a<\/strong> \u7531\u65bc\u795e\u7d93\u53d7\u58d3\u548c\u8840\u6db2\u5faa\u74b0\u53d7\u640d\u3002<\/li>\n<li><strong>\u8178\u80c3\u75c7\u72c0\uff1a<\/strong> \u8179\u8139\u3001\u5641\u5fc3\u6216\u8179\u90e8\u8139\u6c23\uff0c\u4e3b\u8981\u662f\u7531\u65bc\u813e\u5927\u5f15\u8d77\u3002<\/li>\n<\/ul>\n<p class=\"p-cancertype\">\u75c7\u72c0\u6703\u56e0\u75be\u75c5\u7684\u767c\u5c55\u800c\u6709\u986f\u8457\u7684\u5dee\u7570\u3002\u65e9\u671f\u75c7\u72c0\u53ef\u80fd\u8f15\u5fae\u4f46\u660e\u986f\uff0c\u4f8b\u5982\u982d\u75db\u3001\u8f15\u5ea6\u75b2\u52de\u3001\u8f15\u5fae\u75d5\u7662\uff0c\u800c\u665a\u671f\u591a\u8840\u75c7\u97cb\u62c9\u5247\u53ef\u80fd\u5c0e\u81f4\u56b4\u91cd\u4e0d\u9069\u3001\u8996\u529b\u969c\u7919\u3001\u547c\u5438\u6025\u4fc3\uff0c\u4ee5\u53ca\u8840\u6813\u5f62\u6210\u6216\u51fa\u8840\u7684\u98a8\u96aa\u3002<\/p>\n<p class=\"p-cancertype\">\u9019\u4e9b\u75c7\u72c0\u53cd\u6620\u4e86\u9020\u8840\u5e79\u7d30\u80de\u7570\u5e38\u589e\u6b96\u8207\u5206\u5316\u6240\u9a45\u52d5\u7684\u6f5b\u5728\u816b\u7624\u751f\u7269\u5b78\u3002\u591a\u8840\u75c7\u97cb\u62c9\u7d30\u80de\u5728\u6c83\u4f2f\u683c\u6548\u61c9\uff08Warburg effect\uff09\u5f8c\u51fa\u73fe\u7368\u7279\u7684\u65b0\u9673\u4ee3\u8b1d\u6539\u8b8a - \u904e\u5ea6\u651d\u53d6\u8461\u8404\u7cd6\uff0c\u6bd4\u6b63\u5e38\u7d30\u80de\u9ad8\u51fa\u7d04 200 \u500d\uff0c\u5c0e\u81f4\u5168\u8eab\u6027\u65b0\u9673\u4ee3\u8b1d\u4e2d\u65b7\u3002<\/p>\n<p class=\"p-cancertype\">\u53ca\u65e9\u767c\u73fe\u9019\u4e9b\u75c7\u72c0\u53ef\u986f\u8457\u6539\u5584\u9810\u5f8c\u3002\u6211\u5011\u5f37\u70c8\u5efa\u8b70\u60a8\u5728\u51fa\u73fe\u4efb\u4f55\u6301\u7e8c\u75c7\u72c0\u6642\u63a5\u53d7\u91ab\u7642\u8a55\u4f30\u3002<\/p>\n<h2 class=\"h2-cancertype\">\u591a\u8840\u7d30\u80de\u53e2\u751f\u75c7 (PV) \u7684\u5206\u671f\u8207\u5b58\u6d3b\u7387<\/h2>\n<p class=\"p-cancertype\">\u591a\u8840\u75c7\u97cb\u62c9 (PV) \u7684\u9032\u5c55\u5206\u70ba\u4e0d\u540c\u968e\u6bb5\uff0c\u6bcf\u500b\u968e\u6bb5\u90fd\u6709\u5b8c\u5168\u53ef\u8fa8\u8b58\u7684\u75c7\u72c0\u3001\u81e8\u5e8a\u5f71\u97ff\uff0c\u4ee5\u53ca\u5728\u9999\u6e2f\u53ca\u4e9e\u6d32\u5404\u5730\u660e\u986f\u89c0\u5bdf\u5230\u7684\u5b58\u6d3b\u7d50\u679c\u3002\u77ad\u89e3\u9019\u4e9b\u968e\u6bb5\u53ef\u8b93\u60a3\u8005\u53ca\u6642\u63a1\u53d6\u4ecb\u5165\u7b56\u7565\u3002<\/p>\n<h3 class=\"h3-cancertype\">\u7b2c 1 \u671f - \u65e9\u671f\u591a\u8840\u75c7\u97cb\u62c9 (PV)<\/h3>\n<p class=\"p-cancertype\">\u65e9\u671f\u591a\u8840\u75c7\u651c\u5e36\u53ef\u63a7\u5236\u7684\u8840\u6db2\u6210\u4efd\u589e\u52a0\uff0c\u4e0d\u6703\u6709\u660e\u986f\u7684\u4f75\u767c\u75c7\uff1a<\/p>\n<ul class=\"p-cancertype\">\n<li>\u8840\u7d05\u86cb\u767d\u548c\u8840\u7d30\u80de\u6bd4\u5bb9\u6c34\u5e73\u8f15\u5ea6\u5347\u9ad8\u3002<\/li>\n<li>\u813e\u81df\u6216\u809d\u81df\u7121\u660e\u986f\u816b\u5927\uff0c\u75c7\u72c0\u8f15\u5fae\u3002<\/li>\n<li>\u6cbb\u7642\u4e3b\u8981\u8457\u91cd\u65bc\u6cbb\u7642\u6027\u62bd\u8840\u548c\u751f\u6d3b\u65b9\u5f0f\u7684\u6539\u8b8a\u3002<\/li>\n<\/ul>\n<p class=\"p-cancertype\">\u6839\u64da\u6700\u8fd1\u7684\u4e9e\u6d32\u81e8\u5e8a\u7814\u7a76\uff0c\u65e9\u671f\u591a\u8840\u7d30\u80de\u53e2\u751f\u75c7\u7684\u5b58\u6d3b\u7387\u7d04\u70ba 90%+ 5 \u5e74\uff0c\u5b58\u6d3b\u524d\u666f\u975e\u5e38\u4ee4\u4eba\u9f13\u821e\uff0c\u7a81\u986f\u51fa\u65e9\u671f\u767c\u73fe\u548c\u524d\u77bb\u6027\u81e8\u5e8a\u76e3\u6e2c\u7684\u91cd\u8981\u6027\u3002<\/p>\n<h3 class=\"h3-cancertype\">\u7b2c 2 \u671f - \u4e2d\u5ea6\u591a\u8840\u75c7(PV)<\/h3>\n<p class=\"p-cancertype\">\u5728\u4e2d\u578b\u591a\u8840\u75c7\u97cb\u62c9\u4e2d\uff0c\u75be\u75c5\u7684\u9032\u5c55\u958b\u59cb\u6709\u660e\u986f\u7684\u5168\u8eab\u6027\u8868\u73fe\uff1a<\/p>\n<ul class=\"p-cancertype\">\n<li>\u4e2d\u5ea6\u813e\u5927\uff08\u813e\u81df\u816b\u5927\uff09\u5f15\u8d77\u8179\u90e8\u8139\u6c23\u6216\u4e0d\u9069\u3002<\/li>\n<li>\u56e0\u8840\u6db2\u9ecf\u7a20\u5ea6\u800c\u589e\u52a0\u6813\u585e\u98a8\u96aa\u3002<\/li>\n<li>\u9593\u6b47\u6027\u75c7\u72c0\u767c\u4f5c-\u6df1\u975c\u8108\u8840\u6813\u5f62\u6210\u3001\u77ed\u66ab\u6027\u7f3a\u8840\u6027\u767c\u4f5c\u3002<\/li>\n<\/ul>\n<p class=\"p-cancertype\">\u8655\u7406\u65b9\u6cd5\u5305\u62ec\u589e\u52a0\u7d30\u80de\u518d\u751f\u7642\u6cd5\uff0c\u4f8b\u5982\u7fa5\u57fa\u8132\u548c\u5e72\u64fe\u7d20-\u03b1\uff0c\u53ef\u986f\u8457\u6539\u5584\u75c7\u72c0\u8655\u7406\u4e26\u964d\u4f4e\u8840\u6813\u98a8\u96aa\u3002\u5728\u4e9e\u6d32\u7fa4\u9ad4\u4e2d\uff0c\u7d04 70-85% \u7684\u4e94\u5e74\u5b58\u6d3b\u7387\u5f88\u666e\u904d\u3002<\/p>\n<h3 class=\"h3-cancertype\">\u7b2c 3 \u671f - \u665a\u671f\u591a\u8840\u75c7\u97cb\u62c9 (PV)<\/h3>\n<p class=\"p-cancertype\">\u4ee5\u5168\u8eab\u6027\u75c7\u72c0\u4e0d\u65b7\u589e\u52a0\u70ba\u6a19\u8a8c\u7684\u9032\u6b65\u968e\u6bb5\uff1a<\/p>\n<ul class=\"p-cancertype\">\n<li>\u660e\u986f\u813e\u5927\uff0c\u8179\u90e8\u4e0d\u9069\u6025\u5287\u589e\u52a0\u3002<\/li>\n<li>\u983b\u7e41\u7619\u7662\uff0c\u901a\u5e38\u5287\u70c8\u4e14\u5177\u7834\u58de\u6027\u3002<\/li>\n<li>\u8840\u6813\u6216\u51fa\u8840\u4f75\u767c\u75c7\u98a8\u96aa\u5347\u9ad8\u3002<\/li>\n<li>\u9032\u884c\u6027\u8ca7\u8840\u548c\u9ad4\u91cd\u4e0b\u964d\u986f\u793a\u75be\u75c5\u751f\u7269\u5b78\u8f49\u578b\u81f3\u9aa8\u9ad3\u7e96\u7dad\u5316\u3002<\/li>\n<\/ul>\n<p class=\"p-cancertype\">\u6cbb\u7642\u7b56\u7565\u5168\u9762\u64f4\u5c55\u81f3\u7d50\u5408\u591a\u6a21\u5f0f\u7642\u6cd5\uff0c\u4f8b\u5982 JAK2 \u6291\u5236\u5291\uff0c\u518d\u52a0\u4e0a\u652f\u6301\u6027\u8840\u6db2\u5b78\u8b77\u7406\u548c\u4ee3\u8b1d\u7642\u6cd5\u3002\u9999\u6e2f\u548c\u6771\u4e9e\u816b\u7624\u79d1\u7684\u81e8\u5e8a\u7814\u7a76\u986f\u793a\uff0c\u63a1\u7528\u6709\u6548\u7684\u591a\u5b78\u79d1\u6cbb\u7642\u65b9\u6cd5\uff0c\u665a\u671f\u60a3\u8005\u7684\u4e94\u5e74\u5b58\u6d3b\u7387\u4ecb\u65bc 50-70% \u4e4b\u9593\u3002<\/p>\n<h3 class=\"h3-cancertype\">\u7b2c 4 \u671f - \u4fb5\u8972\u6027\u6216\u8f49\u79fb\u6027\u591a\u8840\u7d30\u80de\u7624 (PV)<\/h3>\n<p class=\"p-cancertype\">\u5728\u6975\u5c11\u6578\u7684\u60c5\u6cc1\u4e0b\uff0c\u591a\u8840\u7d30\u80de\u53e2\u7624\u6703\u60e1\u5316\u70ba\u8f49\u79fb\u578b\u767d\u8840\u75c5\u6216\u9aa8\u9ad3\u7e96\u7dad\u5316\uff1a<\/p>\n<ul class=\"p-cancertype\">\n<li>\u5168\u8eab\u5668\u5b98\u4f75\u767c\u75c7\uff0c\u5305\u62ec\u80ba\u90e8\u3001\u809d\u81df\u6216\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\u53d7\u7d2f\u3002<\/li>\n<li>\u6975\u5ea6\u75b2\u52de\u3001\u547c\u5438\u56f0\u96e3\u548c\u75bc\u75db\u6703\u56b4\u91cd\u5f71\u97ff\u751f\u6d3b\u54c1\u8cea\u3002<\/li>\n<li>\u56b4\u91cd\u7d30\u80de\u6e1b\u5c11\u53ca\u8840\u6813\u6216\u51fa\u8840\u4e8b\u4ef6\u7121\u6cd5\u63a7\u5236\u3002<\/li>\n<\/ul>\n<p class=\"p-cancertype\">\u6cbb\u7642\u65b9\u6cd5\u5305\u62ec\u5148\u9032\u7684\u5168\u8eab\u6027\u5316\u7642\u3001\u6a19\u9776\u6cbb\u7642\u3001\u5e79\u7d30\u80de\u79fb\u690d\uff0c\u4ee5\u53ca\u65e8\u5728\u5229\u7528\u764c\u75c7\u7279\u6709\u7684\u4ee3\u8b1d\u6f0f\u6d1e\uff08\u5982\u8c37\u6c28\u9170\u80fa\u4f9d\u8cf4\u6027\uff09\u7684\u958b\u5275\u6027\u4ee3\u8b1d\u65b9\u6cd5\u3002\u5728AllCancer\uff0c\u5275\u65b0\u76844D\u7642\u6cd5\u5229\u7528\u65b0\u9673\u4ee3\u8b1d\u7684\u5f31\u9ede\uff0c\u986f\u793a\u51fa\u826f\u597d\u7684\u53cd\u61c9\u7387\uff0c\u6709\u53ef\u80fd\u5c07\u4fb5\u8972\u6027\u591a\u8840\u7d30\u80de\u53e2\u7624\u8f49\u5316\u70ba\u6162\u6027\u53ef\u63a7\u5236\u7684\u75c5\u75c7\u3002\u5728\u9999\u6e2f\u548c\u66f4\u5ee3\u6cdb\u7684\u4e9e\u6d32\u5730\u5340\uff0c\u5373\u4f7f\u5728\u9019\u500b\u968e\u6bb5\uff0c\u5b58\u6d3b\u7387\u4e5f\u5728\u9010\u6b65\u6539\u5584\uff0c\u76ee\u524d\u5728\u7a4d\u6975\u7684\u4ee3\u8b1d\u9776\u5411\u6cbb\u7642\u5e72\u9810\u4e0b\uff0c\u4e09\u5e74\u5b58\u6d3b\u7387\u7d04\u70ba 20-30%\u3002<\/p>\n<p class=\"p-cancertype\">\u4ee4\u4eba\u9f13\u821e\u7684\u662f\uff0c\u57fa\u65bc\u8afe\u8c9d\u723e\u734e\u7814\u7a76\u7684\u6301\u7e8c\u6cbb\u7642\u5275\u65b0\uff08\u4f8b\u5982 Allison \u535a\u58eb\u7684\u514d\u75ab\u6aa2\u67e5\u9ede\u3001Semenza \u6559\u6388\u7684\u65b0\u9673\u4ee3\u8b1d\u901a\u8def\uff09\u5df2\u958b\u555f\u6539\u5584\u9810\u5f8c\u7684\u8def\u5f91\uff0c\u5c07\u4e00\u5ea6\u7121\u6cd5\u91ab\u6cbb\u7684\u665a\u671f\u591a\u8840\u75c7era \u75c5\u4f8b\u8f49\u8b8a\u70ba\u6162\u6027\u3001\u53ef\u63a7\u5236\u7684\u75be\u75c5\u3002\u6bcf\u5e74\u90fd\u6709\u6210\u5343\u4e0a\u842c\u7684\u75c5\u60a3\u52a0\u5165\u9577\u671f\u5016\u5b58\u8005\u7684\u884c\u5217\uff0c\u5373\u4f7f\u5728\u665a\u671f\u4e5f\u80fd\u56e0 AllCancer \u7d9c\u5408\u7167\u8b77\u9014\u5f91\u800c\u904e\u8457\u512a\u8cea\u7684\u751f\u6d3b\u3002<\/p>\n<h2 class=\"h2-cancertype\">\u591a\u8840\u7d30\u80de\u53e2\u751f\u75c7 (PV) \u50b3\u7d71\u7642\u6cd5\u7684\u9650\u5236<\/h2>\n<p class=\"p-cancertype\">\u9577\u671f\u4ee5\u4f86\uff0c\u5316\u7642\u3001\u653e\u5c04\u6cbb\u7642\u53ca\u624b\u8853\u6cbb\u7642\u7b49\u50b3\u7d71\u6cbb\u7642\u65b9\u5f0f\u4e00\u76f4\u662f\u591a\u767c\u6027\u8840\u75c7(PV)\u7684\u4e3b\u8981\u6cbb\u7642\u7b56\u7565\u3002\u7136\u800c\uff0c\u9019\u4e9b\u6cbb\u7642\u65b9\u6cd5\u7684\u5c40\u9650\u6027\u5c0d\u75c5\u60a3\u7684\u751f\u6d3b\u54c1\u8cea\u548c\u7642\u6548\u9020\u6210\u91cd\u5927\u5f71\u97ff\u3002\u77ad\u89e3\u9019\u4e9b\u9650\u5236\uff0c\u5c31\u80fd\u6e05\u695a\u5730\u770b\u51fa\u6211\u5011\u8feb\u5207\u9700\u8981\u80fd\u514b\u670d\u9019\u4e9b\u969c\u7919\u7684\u5275\u65b0\u7642\u6cd5\u3002<\/p>\n<h3 class=\"h3-cancertype\">\u5316\u7642\u7684\u6bd2\u6027\u8207\u98a8\u96aa<\/h3>\n<p class=\"p-cancertype\">\u5316\u5b78\u6cbb\u7642\u4ecd\u662f\u6cbb\u7642\u591a\u8840\u7403\u53e2\u751f\u75c7 (PV) \u7684\u57fa\u77f3\u3002\u5118\u7ba1\u5982\u6b64\uff0c\u9019\u7a2e\u50b3\u7d71\u7684\u6cbb\u7642\u65b9\u5f0f\u4ecd\u6709\u5f88\u5927\u7684\u6bd2\u6027\u98a8\u96aa\u3002JAMA Oncology (2023) \u7684\u8cc7\u6599\u5f37\u8abf\u5316\u7642\u76f8\u95dc\u7684\u6bd2\u6027\uff0c\u5c24\u5176\u662f\u9aa8\u9ad3\u6291\u5236\u3001\u5fc3\u81df\u6bd2\u6027\u3001\u7e7c\u767c\u60e1\u6027\u816b\u7624\u98a8\u96aa\u548c\u6162\u6027\u75b2\u52de\u3002<\/p>\n<ul class=\"p-cancertype\">\n<li><strong>\u9aa8\u9ad3\u6291\u5236\uff1a<\/strong> \u7d04\u6709 78% \u7684\u5316\u7642\u75c5\u60a3\u6703\u7d93\u6b77\u56b4\u91cd\u7684\u9aa8\u9ad3\u6291\u5236\u3002\u9019\u7a2e\u4e0d\u826f\u53cd\u61c9\u6703\u640d\u5bb3\u514d\u75ab\u7cfb\u7d71\uff0c\u4f7f\u75c5\u60a3\u5bb9\u6613\u53d7\u5230\u611f\u67d3\uff0c\u4e26\u5927\u5e45\u5ef6\u9577\u4f4f\u9662\u6642\u9593\u3002<\/li>\n<li><strong>\u5fc3\u81df\u6bd2\u6027\uff1a<\/strong> \u7d04\u6709 23% \u5316\u7642\u75c5\u60a3\u6703\u51fa\u73fe\u5fc3\u81df\u6bd2\u6027\u75c7\u72c0\u3002\u9019\u53ef\u80fd\u8868\u73fe\u70ba\u5fc3\u5f8b\u4e0d\u6574\u3001\u5fc3\u81df\u529f\u80fd\u6e1b\u5f31\u4ee5\u53ca\u5fc3\u8840\u7ba1\u98a8\u96aa\u5927\u5e45\u589e\u52a0\uff0c\u5c24\u5176\u662f\u4e9e\u6d32\u4eba\u53e3\u4e2d\u7684\u5e74\u9577\u75c5\u60a3\uff0c\u4ed6\u5011\u7684\u5fc3\u8840\u7ba1\u4f75\u767c\u75c7\u5df2\u7d93\u76f8\u7576\u9ad8\u3002<\/li>\n<li><strong>\u7e7c\u767c\u6027\u764c\u75c7\u98a8\u96aa\uff1a<\/strong> \u6709\u8b49\u64da\u986f\u793a\uff0c\u5316\u7642\u5f8c\u51fa\u73fe\u7e7c\u767c\u6027\u764c\u75c7\u7684\u53ef\u80fd\u6027\u5927\u5e45\u589e\u52a0\u81f3 300%\uff08JAMA Oncology\uff0c2023\uff09\u3002\u56e0\u6b64\uff0c\u591a\u8840\u7d30\u80de\u7624 (PV) \u7684\u9577\u671f\u5b58\u6d3b\u8005\u9762\u81e8\u6f5b\u5728\u7684\u7e7c\u767c\u6027\u60e1\u6027\u816b\u7624\uff0c\u5927\u5e45\u964d\u4f4e\u6574\u9ad4\u5b58\u6d3b\u7387\u4e26\u589e\u52a0\u91ab\u7642\u8ca0\u64d4\u3002<\/li>\n<\/ul>\n<h3 class=\"h3-cancertype\">\u653e\u5c04\u6cbb\u7642\u7684\u56b4\u91cd\u526f\u4f5c\u7528<\/h3>\n<p class=\"p-cancertype\">\u5118\u7ba1\u653e\u5c04\u6cbb\u7642\u5728\u63a7\u5236\u8840\u6db2\u7cfb\u7d71\u60e1\u6027\u816b\u7624 (\u5982\u591a\u8840\u7d30\u80de\u7624) \u7684\u521d\u671f\u975e\u5e38\u6709\u7528\uff0c\u4f46\u537b\u6703\u7522\u751f\u56b4\u91cd\u7684\u526f\u4f5c\u7528\u3002\u9999\u6e2f\u53ca\u4e9e\u6d32\u5730\u5340\u7684\u60a3\u8005\u5728\u63a5\u53d7\u653e\u5c04\u6cbb\u7642\u5f8c\uff0c\u6301\u7e8c\u5831\u544a\u51fa\u4e0d\u826f\u7684\u81e8\u5e8a\u7d50\u679c\uff1a<\/p>\n<ul class=\"p-cancertype\">\n<li><strong>\u7d44\u7e54\u640d\u50b7\uff1a<\/strong> \u9ad8\u80fd\u91cf\u8f3b\u5c04\u6703\u640d\u5bb3\u5468\u570d\u7684\u5065\u5eb7\u7d44\u7e54\u548c\u60e1\u6027\u7d30\u80de\uff0c\u5c0e\u81f4\u6162\u6027\u75bc\u75db\u3001\u7e96\u7dad\u5316\u548c\u4e0d\u53ef\u9006\u7684\u7d44\u7e54\u50b7\u5bb3\u3002\u6b64\u5916\uff0c\u8f3b\u5c04\u5340\u57df\u7684\u9130\u8fd1\u5340\u57df\u6703\u51fa\u73fe\u7652\u5408\u969c\u7919\u548c\u6301\u7e8c\u6027\u767c\u708e\u3002<\/li>\n<li><strong>\u6162\u6027\u75b2\u52de\u8207\u964d\u4f4e\u751f\u6d3b\u54c1\u8cea\uff1a<\/strong> \u63a5\u53d7\u653e\u5c04\u7dda\u6cbb\u7642\u7684\u75c5\u60a3\u901a\u5e38\u90fd\u6703\u6709\u6162\u6027\u75b2\u52de\u7684\u8ca0\u64d4\uff0c\u9019\u56b4\u91cd\u5f71\u97ff\u5230\u65e5\u5e38\u6d3b\u52d5\u548c\u6574\u9ad4\u60c5\u7dd2\u3002\u9019\u7a2e\u75b2\u52de\u901a\u5e38\u6703\u5728\u653e\u5c04\u6cbb\u7642\u7d50\u675f\u5f8c\u6301\u7e8c\u5f88\u4e45\u3002<\/li>\n<li><strong>\u7e7c\u767c\u6027\u60e1\u6027\u816b\u7624\uff1a<\/strong> \u8f3b\u5c04\u7167\u5c04\u5df2\u88ab\u8b49\u5be6\u6703\u589e\u5f37\u7a81\u8b8a\uff0c\u5927\u5e45\u589e\u52a0\u7f79\u60a3\u7e7c\u767c\u6027\u764c\u75c7\u7684\u98a8\u96aa\u3002\u6839\u64da\u4e9e\u6d32\u7684\u6d41\u884c\u75c5\u5b78\u8cc7\u6599\u986f\u793a\uff0c\u906d\u53d7\u8f3b\u5c04\u7684\u75c5\u60a3\u5728\u5176\u5f8c\u6578\u5e74\u9593\u7f79\u60a3\u7e7c\u767c\u6027\u60e1\u6027\u816b\u7624\u7684\u6a5f\u7387\u660e\u986f\u8f03\u9ad8\u3002<\/li>\n<\/ul>\n<h3 class=\"h3-cancertype\">\u624b\u8853\u4ecb\u5165\u7684\u6311\u6230\u8207\u98a8\u96aa<\/h3>\n<p class=\"p-cancertype\">\u96d6\u7136\u813e\u81df\u5207\u9664\u8853\u7b49\u624b\u8853\u6cbb\u7642\u662f\u9078\u64c7\u6027\u5be6\u65bd\u7684\uff0c\u4f46\u5b83\u5011\u4e5f\u6709\u5be6\u8cea\u7684\u98a8\u96aa\uff0c\u5305\u62ec\uff1a<\/p>\n<ul class=\"p-cancertype\">\n<li><strong>\u611f\u67d3\uff1a<\/strong> \u624b\u8853\u904e\u7a0b\u4e2d\u6703\u6709\u611f\u67d3\u98a8\u96aa\uff0c\u589e\u52a0\u767c\u75c5\u7387\u548c\u6b7b\u4ea1\u7387\u3002\u7d04\u6709 15% \u7684\u624b\u8853\u75c5\u4f8b\u6703\u9047\u5230\u611f\u67d3\u4f75\u767c\u75c7\uff0c\u5c24\u5176\u662f\u514d\u75ab\u529b\u4f4e\u4e0b\u7684\u591a\u767c\u6027\u8840\u75c7(PV)\u60a3\u8005\u3002<\/li>\n<li><strong>\u51fa\u8840\u8207\u5fa9\u539f\u554f\u984c\uff1a<\/strong> \u51fa\u8840\u4e8b\u6545\u7684\u589e\u52a0\u548c\u6062\u5fa9\u968e\u6bb5\u7684\u5ef6\u9577\u70ba\u624b\u8853\u6cbb\u7642\u589e\u52a0\u4e86\u660e\u986f\u7684\u9650\u5236\u3002\u75c5\u4eba\u5728\u624b\u8853\u5f8c\u901a\u5e38\u9700\u8981\u8f03\u9577\u7684\u6062\u5fa9\u671f\uff0c\u9019\u6703\u6d88\u8017\u91cd\u8981\u7684\u91ab\u9662\u8cc7\u6e90\uff0c\u4e26\u964d\u4f4e\u4e9e\u6d32\u91ab\u9662\u7684\u6574\u9ad4\u75c5\u60a3\u8655\u7406\u91cf\u3002<\/li>\n<li><strong>\u9ebb\u9189\u4f75\u767c\u75c7\uff1a<\/strong> \u8207\u9ebb\u9189\u76f8\u95dc\u7684\u98a8\u96aa\u9032\u4e00\u6b65\u589e\u52a0\u4e86\u6cbb\u7642\u7684\u5371\u96aa\u6027\uff0c\u5c24\u5176\u662f\u5728\u9999\u6e2f\u548c\u65b0\u52a0\u5761\u7b49\u9ad8\u98a8\u96aa\u5730\u5340\u5e38\u898b\u7684\u5e74\u9577\u6216\u91ab\u7642\u72c0\u6cc1\u4e0d\u4f73\u7684\u75c5\u60a3\u3002<\/li>\n<\/ul>\n<h3 class=\"h3-cancertype\">\u665a\u671f\u591a\u8840\u7d30\u80de\u53e2\u751f\u75c7 (PV) \u7684\u7642\u6548\u8f03\u4f4e<\/h3>\n<p class=\"p-cancertype\">\u4ee4\u4eba\u9707\u60ca\u7684\u662f\uff0c\u4f20\u7edf\u7597\u6cd5\u5bf9\u665a\u671f\u591a\u53d1\u6027\u7ea2\u7ec6\u80de\u75c7\uff08PV\uff09\u7684\u7597\u6548\u975e\u5e38\u4f4e\u3002\u5728\u51fa\u73fe\u8f49\u79fb\u6027\u6216\u665a\u671f\u75be\u75c5\u7684\u60a3\u8005\u4e2d\uff0c\u5ba2\u89c0\u53cd\u61c9\u7387 (ORR) \u5927\u5e45\u4e0b\u964d\u81f3 21% \u4ee5\u4e0b\uff1a<\/p>\n<ul class=\"p-cancertype\">\n<li>\u6700\u8fd1\u7684\u7814\u7a76\uff08JAMA Oncology 2023\uff09\u6307\u51fa\uff0c\u50b3\u7d71\u7684\u65b9\u6cd5\u5f88\u5c11\u80fd\u9054\u5230\u6301\u7e8c\u6027\u7684\u7de9\u89e3\uff0c\u5c24\u5176\u662f\u5c0d\u65bc\u8f49\u79fb\u6027\u75be\u75c5\uff0c\u764c\u7d30\u80de\u6703\u8b8a\u5f97\u9ad8\u5ea6\u589e\u6b96\u3001\u9069\u61c9\u6027\u5f37\uff0c\u4e26\u5c0d\u50b3\u7d71\u63a1\u7528\u7684\u7642\u6cd5\u7522\u751f\u6297\u85e5\u6027\u3002<\/li>\n<li>\u56e0\u6b64\uff0c\u665a\u671f\u60a3\u8005\u7d93\u5e38\u5c0d\u6a19\u6e96\u7684\u8840\u6db2\u816b\u7624\u5b78\u6cbb\u7642\u7121\u53cd\u61c9\uff0c\u9019\u5728\u9999\u6e2f\u548c\u6574\u500b\u4e9e\u6d32\u90fd\u662f\u56b4\u91cd\u7684\u81e8\u5e8a\u9650\u5236\u3002<\/li>\n<\/ul>\n<h3 class=\"h3-cancertype\">\u4ee3\u8b1d\u62b5\u6297\u6a5f\u5236<\/h3>\n<p class=\"p-cancertype\">\u65b0\u9673\u4ee3\u8b1d\u6297\u85e5\u6027\u662f\u50b3\u7d71\u7642\u6cd5\uff0c\u5c24\u5176\u662f\u5316\u7642\u548c\u653e\u5c04\u6cbb\u7642\u7684\u53e6\u4e00\u500b\u969c\u7919\u3002\u591a\u8840\u7d30\u80de\u7624 (Polycythemia Vera, PV) \u7d30\u80de\u7684\u65b0\u9673\u4ee3\u8b1d\u9069\u61c9\u6027\u589e\u5f37\uff0c\u8ce6\u4e88\u4e86\u6297\u85e5\u6a5f\u5236\uff0c\u64f4\u5927\u4e86\u6cbb\u7642\u4e0a\u7684\u6311\u6230\uff1a<\/p>\n<ul class=\"p-cancertype\">\n<li><strong>\u6c83\u4f2f\u683c\u6548\u61c9\u548c\u7cd6\u9175\u89e3\u4f9d\u8cf4\uff1a<\/strong> \u764c\u7d30\u80de\u900f\u904e\u4e00\u7a2e\u540d\u70ba Warburg \u6548\u61c9\u7684\u65b0\u9673\u4ee3\u8b1d\u7279\u6027\u800c\u8301\u58ef\u6210\u9577\u3002\u9019\u7a2e\u73fe\u8c61\u4f7f\u7d30\u80de\u6d88\u8017\u8461\u8404\u7cd6\u7684\u901f\u5ea6\u6bd4\u6b63\u5e38\u901f\u5ea6\u9ad8\u51fa 200 \u500d\u4ee5\u4e0a\uff0c\u5f37\u5927\u5730\u4fdd\u8b77\u5b83\u5011\u514d\u53d7\u50b3\u7d71\u7642\u6cd5\u7684\u50b7\u5bb3\u3002<\/li>\n<li><strong>\u589e\u5f37 DNA \u4fee\u5fa9\u6d3b\u6027\uff1a<\/strong> \u764c\u7d30\u80de\u986f\u793a\u51fa DNA \u4fee\u5fa9\u9175\u7d20\u4e0a\u8abf (\u6bd4\u6b63\u5e38\u7d30\u80de\u9ad8\u51fa\u7d04 400%)\u3002\u9019\u7279\u5225\u964d\u4f4e\u4e86\u5316\u7642\u548c\u653e\u5c04\u6cbb\u7642\u8a98\u5c0e\u60e1\u6027\u7d30\u80de\u51cb\u4ea1\u7684\u80fd\u529b\uff0c\u4f7f\u6cbb\u7642\u7d50\u679c\u986f\u8457\u60e1\u5316\u3002<\/li>\n<li><strong>Glutamine Dependency\uff1a<\/strong> \u591a\u8840\u7403\u7624 (PV) \u764c\u7d30\u80de\u5177\u6709\u8c37\u6c28\u9170\u80fa\u4f9d\u8cf4\u6027\uff0c\u53ef\u5c07\u65b0\u9673\u4ee3\u8b1d\u9700\u6c42\u8f49\u79fb\u5230\u66ff\u4ee3\u901a\u8def\uff0c\u4f7f\u5176\u5728\u6cbb\u7642\u58d3\u529b\u4e0b\u5b58\u6d3b\uff0c\u6700\u7d42\u62b5\u6297\u50b3\u7d71\u4e0a\u7531\u5316\u7642\u548c\u653e\u5c04\u6240\u9020\u6210\u7684\u50b7\u5bb3\u3002<\/li>\n<\/ul>\n<h3 class=\"h3-cancertype\">\u7d50\u8ad6\uff1a\u6539\u5584\u6cbb\u7642\u5275\u65b0\u7684\u5fc5\u8981\u6027<\/h3>\n<p class=\"p-cancertype\">\u591a\u8840\u7d30\u80de\u53e2\u751f\u75c7\uff08Polycythemia Vera\uff0c\u7c21\u7a31 PV\uff09\u7684\u50b3\u7d71\u7642\u6cd5\u5b58\u5728\u56b4\u91cd\u7684\u5c40\u9650\u6027\uff0c\u5305\u62ec\u6bd2\u6027\u3001\u665a\u671f\u7642\u6548\u964d\u4f4e\u3001\u60e1\u6027\u7d30\u80de\u4ee3\u8b1d\u9748\u6d3b\u6027\u4ee5\u53ca\u6709\u5bb3\u7684\u526f\u4f5c\u7528\uff0c\u9019\u7a81\u986f\u4e86\u9999\u6e2f\u4e43\u81f3\u6574\u500b\u4e9e\u6d32\u7684\u81e8\u5e8a\u91ab\u751f\u548c\u60a3\u8005\u6240\u9762\u81e8\u7684\u5de8\u5927\u6311\u6230\u3002\u9019\u4e9b\u6311\u6230\u51f8\u986f\u4e86\u6211\u5011\u8feb\u5207\u9700\u8981\u8f49\u5411\u5229\u7528\u65b0\u578b\u4ee3\u8b1d\u9776\u9ede\u3001\u500b\u4eba\u5316\u91ab\u5b78\u548c\u9776\u5411\u751f\u7269\u65b9\u6cd5\u7684\u5275\u65b0\u7642\u6cd5\u3002\u4ee4\u4eba\u9f13\u821e\u7684\u662f\uff0c\u7531\u674e\u570b\u83ef\u535a\u58eb\u548c\u5289\u570b\u9f8d\u6559\u6388\u7b49\u5c08\u5bb6\u958b\u5275\u7684\u65b0\u9673\u4ee3\u8b1d\u816b\u7624\u5b78\u7642\u6cd5\u7b49\u65b9\u9762\u7684\u9032\u5c55\u5e36\u4f86\u4e86\u986f\u8457\u7684\u524d\u666f\u3002\u9019\u4e9b\u5d84\u65b0\u7684\u7642\u6cd5\u7372\u5f97\u8afe\u8c9d\u723e\u734e\u5f97\u4e3b\u7684\u79d1\u5b78\u7814\u7a76\u3001\u6cd5\u898f\u6838\u51c6\uff0c\u4e26\u8b49\u5be6\u6709\u8f03\u9ad8\u7684 ORR\uff0c\u5176\u76ee\u7684\u5728\u65bc\u6e1b\u8f15\u9019\u4e9b\u95dc\u9375\u6027\u7684\u7f3a\u9ede\uff0c\u4f7f\u5176\u6210\u70ba\u591a\u767c\u6027\u7d05\u6591\u816b\u7624 (PV) \u8b77\u7406\u4e2d\u5099\u53d7\u671f\u5f85\u4e14\u524d\u666f\u770b\u597d\u7684\u9078\u64c7\u3002<\/p>","protected":false},"excerpt":{"rendered":"<p>What Is Polycythemia Vera (PV)? Polycythemia Vera (PV) is a rare, chronic blood cancer characterized by an abnormal, uncontrolled proliferation of red blood cells within the bone marrow. This increased production leads to a thickening of the blood (hyperviscosity), significantly heightening the risk of blood clots (thrombosis), strokes, and heart attacks. The biological underpinning of [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":7432,"parent":0,"menu_order":0,"template":"","class_list":["post-7836","cancer_type","type-cancer_type","status-publish","has-post-thumbnail","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/allcancer.com\/hk\/wp-json\/wp\/v2\/cancer_type\/7836","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/allcancer.com\/hk\/wp-json\/wp\/v2\/cancer_type"}],"about":[{"href":"https:\/\/allcancer.com\/hk\/wp-json\/wp\/v2\/types\/cancer_type"}],"author":[{"embeddable":true,"href":"https:\/\/allcancer.com\/hk\/wp-json\/wp\/v2\/users\/3"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/allcancer.com\/hk\/wp-json\/wp\/v2\/media\/7432"}],"wp:attachment":[{"href":"https:\/\/allcancer.com\/hk\/wp-json\/wp\/v2\/media?parent=7836"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}